Uber faced regulatory barriers and opposition from numerous municipal and state agencies. These included the Taxi Commissions, Departments of Transportation, Departments of Insurance, and Public Utility Commissions. Resistance also came from mayors, governors, state legislators, and city council members who have long-standing relationships with the taxi industry.

• In 2011, Tusk began helping Uber assess the situation in key markets, build the right team on the ground, manage the regulatory process and eventually put a long-term leadership team in place.
• In 2015, when NYC sought to cap Uber's growth, Tusk led efforts to defeat the legislation in a multi-faceted campaign. Tusk directed earned media efforts, launched a multi-million dollar advertising blitz, rallied users via targeted advertising (even within the Uber app itself), engaged natural allies from the tech world, leveraged the fractious relationship between the Mayor and other city and state elected officials, and secured additional pressure from officials normally allied with City Hall.

With the help of Tusk's team, Uber went from operating only in San Francisco to launching multi-pronged campaigns to key markets around the country, and then the world.